Connect Sign In
Autoimmune Neuromuscular Junction Reflexive Panel
Ordering Recommendation
Aids in the diagnosis of a broad range of acquired neuromuscular junction (NMJ) disorders. For the initial evaluation of myasthenia gravis, refer to Myasthenia Gravis Reflexive Panel (3001869).
New York DOH Approval Status
Specimen Required
Serum separator tube (SST).
Separate serum from cells ASAP or within 2 hours of collection. Transport 2 mL serum. (Min: 1 mL)
Refrigerated.
Plasma. Contaminated, hemolyzed, or severely lipemic specimens.
Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 year
Methodology
Quantitative Radioimmunoassay/Qualitative Radiobinding Assay/Semi-Quantitative Flow Cytometry/Semi-Quantitative Indirect Fluorescent Antibody
Performed
Tue
Reported
2-8 days
Reference Interval
| Test Number |
Components |
Reference Interval |
|---|---|---|
| Striated Muscle Antibodies, IgG Screen | Less than 1:40 | |
| Acetylcholine Binding Antibody | 0.4 nmol/L or less | |
| P/Q-Type Calcium Channel Antibody | 24.5 pmol/L or less | |
| Acetylcholine Blocking Antibody | 26 or less blocking | |
| Voltage-Gated Potassium Channel Ab, Ser | 31 pmol/L or less | |
| Titin Antibody | 0.45 IV or less | |
| N-Type Calcium Channel Antibody | 69.9 pmol/L or less | |
| Ganglionic Acetylcholine Receptor Ab | 8.4 pmol/L or less |
Interpretive Data
Refer to report.
| Component | Interpretation |
|---|---|
| Acetylcholine Receptor Binding Antibody | 0.0-0.4 nmol/L Negative 0.5 nmol/L or greater Positive |
| Acetylcholine Receptor Blocking Antibody | 0-26% blocking Negative 27-41% blocking Indeterminate 42% or greater blocking Positive |
| P/Q-Type Voltage-Gated Calcium Channel (VGCC) Antibody | 0.0 to 24.5 pmol/L Negative 24.6 to 45.6 pmol/L Indeterminate 45.7 pmol/L or greater Positive |
| Voltage-Gated Potassium Channel (VGKC) Antibody, Serum | 31 pmol/L or less Negative 32-87 pmol/L Indeterminate 88 pmol/L or greater Positive |
| Titin Antibody | 0.00-0.45 IV Negative 0.46-0.71 IV Indeterminate 0.72 IV or greater Positive |
| N-Type Calcium Channel Antibody | 0.0 to 69.9 pmol/L Negative 70.0 to 110.0 pmol/L Indeterminate 110.1 pmol/L or greater Positive |
| Ganglionic Acetylcholine Receptor Antibody | 0.0 - 8.4 pmol/L Negative 8.5 - 11.6 pmol/L Indeterminate 11.7 pmol/L or greater Positive |
Laboratory Developed Test (LDT)
Note
If Acetylcholine Receptor Binding Antibody result is greater than 0.4 nmol/L or Acetylcholine Receptor Blocking Antibody result is greater than 26 percent, then Acetylcholine Receptor Modulating Antibody will be added. If Striated Muscle Ab is detected, then a titer will be added. If VGKC is Indeterminate or Positive, LGI1 Antibody IgG and CASPR2 Antibody IgG will be added. If LGI1 antibody IgG is positive, then LGI1 antibody IgG titer will be added. If CASPR2 antibody IgG is positive, then CASPR2 antibody IgG titer will be added. Additional charges apply.
Hotline History
Hotline History
CPT Codes
83519 x2; 83516; 86041; 86042; 86255; 86596 x2; if reflexed, add 86043; 86255 x2; 86256 x3
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 0050747 | Striated Muscle Antibodies, IgG Screen | 49692-7 |
| 0080009 | Acetylcholine Binding Antibody | 11034-6 |
| 0092629 | P/Q-Type Calcium Channel Antibody | 33980-4 |
| 0099580 | Acetylcholine Blocking Antibody | 42937-3 |
| 2004890 | Voltage-Gated Potassium Channel Ab, Ser | 41871-5 |
| 2005637 | Titin Antibody | 100371-4 |
| 3002047 | N-Type Calcium Channel Antibody | 33979-6 |
| 3003019 | Ganglionic Acetylcholine Receptor Ab | 42233-7 |
